AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biological, pathological, immunophenotypic, and prognostic features
نویسندگان
چکیده
Claudia Haferlach, Cristina Mecucci, Susanne Schnittger, Alexander Kohlmann, Marco Mancini, Antonio Cuneo, Nicoletta Testoni, Giovanna Rege-Cambrin, Antonella Santucci, Marco Vignetti, Paola Fazi, Maria Paola Martelli, Torsten Haferlach, and Brunangelo Falini Munich Leukemia Laboratory GmbH, Munich, Germany; Institute of Hematology, University of Perugia, Perugia, Italy; Department of Cellular Biotechnologies and Hematology, “La Sapienza” University, Rome, Italy; Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy; Institute of Hematology “Ludovico & Ariosto Seragnoli”, University of Bologna, Bologna, Italy; Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy; GIMEMA Data Center, GIMEMA Foundation, Rome, Italy.
منابع مشابه
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features.
Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93 of 631 cases (14.7%), the most frequent abnormalities being +8, +4, -Y, del(9q), +21. Chromosome aberrations i...
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1Munich Leukemia Laboratory GmbH, Munich, Germany; 2Institute of Hematology, University of Perugia, Perugia, Italy; 3Department of Cellular Biotechnologies and Hematology, “La Sapienza” University, Rome, Italy; 4Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy; 5Institute of Hematology “Ludovico & Ariosto Seragnoli,” University of Bologna, Bologna,...
متن کاملIncidence and Prognostic Value of NPM1 and FLT3 Gene Mutations in AML with Normal Karyotype
NPM1 belongs to a new category of genes that function both as oncogenes and tumor suppressor genes, depending on gene dosage, expression levels, interacting partners, and compartmentalization. Nucleophosmin mutations within exon 12 have been described as the most frequent acquired molecular abnormalities in adult and pediatric acute myeloid leukaemia (AML), mutation can be observed in nearly ha...
متن کاملNucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.
Nucleophosmin (NPM1) exon-12 gene mutations are the hallmark of a large acute myelogenous leukemia (AML) subgroup with normal karyotype, but their prognostic value in this AML subset has not yet been determined. We screened 401 AML patients with normal karyotype treated within the German AML Cooperative Group Protocol 99 (AMLCG99) study for NPM1 mutations. Results were related with partial tand...
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Acute myeloid leukemia carrying cytoplasmic mutated nucleophosmin (NPMc(+) AML) and blastic plasmacytoid dendritic cell neoplasm have been included as new entities in the 4(th) edition (2008) WHO classification of myeloid neoplasms. These conditions may show clinical and pathological overlapping features (leukemic and skin involvement, and expression of macrophage markers). In this study, we pr...
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تاریخ انتشار 2009